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KMID : 0352419930120030286
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Keimyung Medical Journal
1993 Volume.12 No. 3 p.286 ~ p.291
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Cytokine (IL1β, IL6, TNF) Levels of the Cord and Newborn Blood
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Abstract
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The cvtokines, interleukin-1β(IL1β), interleukin-6(IL6) and tumor necrosis factor(TNF) are important mediators of host response to stress and infection. Impaired immune reaction febrile responses to the infection in newborn period may results
from
abnormal cytokine regulation and there were difference in the responses between newborn and adult due to the different cytokine regulation system.
To investigate the cytokine regulation in different circumstances of the delivery and newborn conditions, the measurement of the levels of IL1β, IL6 and TNF in cord blood, amniotic fluid and the blood of the newborn were performed, using enzyme
linked
immunosorbent assay(ELISA, R&D Co.). Cytokines of the supernatant of incubated cellular pellet were also measured.
Cord blood IL1βlevel was significantly higher in induced vaginal delivery than that of the normal vaginal, emergency, and elective cesarian section delivery(p<0.001).
Plasma IL1βlevel of the newborn with infection or stress was elevated and the level was higher in infection than that of the newborn with stress during delivery.
Premature baby had higher level than normal newborn.
Cord blood IL1βlevel was lower than that of amniotic fluid in elective cesarian section delivery.
In normal vaginal delivery. IL1βlevel of the cellular supernatant was higher than that of the plasma and showed good correlation(r=0.92, p<0.05).
In newborn with infection, plasma IL1βlevel was high in the cases with low supernatant level and the plasma level was low in the cases with high supernatant IL1β.
Il6 was detcted form the plasma and cellular supernatant of the newborn with infection and the amniotic fluid.
TNF was detected in cellular supernatant of 3 among 8 newborn with infection.
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KEYWORD
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